Tank blood
Receives about 1500 ml / min (PV = 1100 ml / min and AH = 400 ml / min)
always contains 450 ml (10% blood volume). Can s'expandre (1.5 l) in heart failure.
always contains 450 ml (10% blood volume). Can s'expandre (1.5 l) in heart failure.
Role immune
- Lymphatics
- Liver Macrophages (Kupffer cells)
- Liver Macrophages (Kupffer cells)
metabolic function
Carbohydrate metabolism: important role in maintaining blood glucose:
- Storage of glucose as glycogen .
- Release of glucose from glycogen (glycogenolysis).
- Synthesis of glucose from amino acids and fatty acids (gluconeogenesis).
- Storage of glucose as glycogen .
- Release of glucose from glycogen (glycogenolysis).
- Synthesis of glucose from amino acids and fatty acids (gluconeogenesis).
Lipid metabolism:
- Fatty acid oxidation (energy production).
- Synthesis of lipoprotein (lipid transport).
- Synthesis of cholesterol (adrenal hormones, ovarian and testicular).
- Conversion of glucose to fat and protein (storage).
- Fatty acid oxidation (energy production).
- Synthesis of lipoprotein (lipid transport).
- Synthesis of cholesterol (adrenal hormones, ovarian and testicular).
- Conversion of glucose to fat and protein (storage).
protein metabolism:
- deamination and transamination.
- Synthesis of urea (ammonia removal).
- Synthesis of nearly 90% of plasma proteins (albumin ,...).
- deamination and transamination.
- Synthesis of urea (ammonia removal).
- Synthesis of nearly 90% of plasma proteins (albumin ,...).
Extras
- Storage of certain vitamins: Vitamin A + + +, D, B12.
- Synthesis of some coagulation factors:
- Dependent on Vitamin K: II, VII, IX, X.
- independent of vitamin K: V.
- Storage of free iron in the hemoglobin content (related to ferritin).
- Metabolism of certain drugs and hormones.
- Synthesis of some coagulation factors:
- Dependent on Vitamin K: II, VII, IX, X.
- independent of vitamin K: V.
- Storage of free iron in the hemoglobin content (related to ferritin).
- Metabolism of certain drugs and hormones.
Formation of bile
It is continuously secreted by the liver and is stored in the gallbladder which normally sends in the duodenum and intermittently during digestion. The order of the gallbladder is nervous and humoral.
Bile consists of:
- Water.
- Mucin.
- Minerals.
- Cholesterol.
- bile pigments.
Its role is to assist in the digestion of fats and the role of alkalinization of the chyme.
- Water.
- Mucin.
- Minerals.
- Cholesterol.
- bile pigments.
Its role is to assist in the digestion of fats and the role of alkalinization of the chyme.
Detoxification of endogenous toxins and exogenous
- Endogenous: hormones.
- Exogenous: alcohol and drugs.
- Role of conjugation: bilirubin + Glucuronic acid => water solubility.
- Exogenous: alcohol and drugs.
- Role of conjugation: bilirubin + Glucuronic acid => water solubility.
Role metabolic
on proteins: synthesizes plasma proteins (albumin and glabuline) and coagulation factors (fibrinogen).
on lipids: synthesizes cholesterol (bile composition).
on carbohydrates:
- glycogenesis: production of glycogen.
- Glycogenolysis: conversion into glucose.
- gluconeogenesis: fabricationde glycogen with amino acids.
on lipids: synthesizes cholesterol (bile composition).
on carbohydrates:
- glycogenesis: production of glycogen.
- Glycogenolysis: conversion into glucose.
- gluconeogenesis: fabricationde glycogen with amino acids.
In the liver, there are enzymes: ASAT, ALAT that allow these changes, if these enzymes increase is synonymous cytolysis.
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